This file was created by the Typo3 extension sevenpack version 0.7.16 --- Timezone: CEST Creation date: 2024-04-20 Creation time: 04-42-45 --- Number of references 16 article 40 Progress in Neuropsychopharmacology and Biological Psychiatry 2018 Schizophrenia as a single liability model was confronted to the multiple psychotic phenotypes model proposed by the Wernicke-Kleist-Leonhard school, focusing on two: periodic catatonia (PC) and cataphasia (C). Both are stable and heritable psychotic phenotypes with no crossed liability and are coming with the buildup of specific residual symptoms: impairment of psychomotricity for PC and a specific disorganization of thought and language in C. Regional cerebral blood flow (rCBF) was used as a biomarker. We attempted to refute the single phenotype model by looking at relevant and specific rCBF anomalies for PC and C, that would exceed anomalies in common relative to controls (CTR), i.e. looking for a double dissociation. Twenty subjects with PC, 9 subjects with C and 27 matched controls had two MRI QUIPSS-II arterial spin labeling sequences converted in rCBF. One SPM analysis was performed for each rCBF measurement and the results were given as the conjunction of both analysis. There was a clear double dissociation of rCBF correlates between PC and C, both being meaningful relative to their residual symptomatology. In PC: rCBF was increased in the left motor and premotor areas. In C: rCBF was decreased bilaterally in the temporo-parietal junctions. Conversely, in both (schizophrenia): rCBF was increased in the left striatum which is known to be an anti-psychotics’ effect. These evidences refuted the single schizophrenia model and suggested better natural foundations for PC and C phenotypes. They plead for further research on them and further research on naturally founded psychotic phenotypes. WKL; connect fileadmin/cep_files/Articles/A_double_dissociation_between_two_psychotic_phenotypes-Periodic_catatonia_and_cataphasia.pdf fileadmin/Cours/Psychopatho/Divers/A_Double_Dissociation/index.html Jack RFoucher Yi FanZhang MathildeRoser JulienLamy Paulo Loureirode Sousa SébastienWeibel PierreVidailhet OlivierMainberger FabriceBerna book 503 2014 426#1891 Books on demand, Paris Traduction 978-2-3220-3850-3 Jack RFoucher FabriceBerna JulienElowe article 1003 Conscious Cogn 2012 21 90-99 Disturbances of perception of subjective time have been described in schizophrenia but have not been experimentally studied until now. We investigated how patients with schizophrenia estimate the subjective temporal distance (TD) of past personal events, i.e. how these events are perceived as subjectively close or distant in time. Twenty-five patients with schizophrenia and 25 control participants recalled 24 autobiographical memories from four different life periods. They estimated the subjective TD and rated the amount of detail of each memory. Results showed that patients with schizophrenia had a distorted perception of subjective TD. Their memories were significantly less detailed than those of controls and, unlike control participants, the amount of memory detail was not significantly correlated with subjective TD. Poor access to memory detail may account for distortions of perception of subjective time in patients with schizophrenia. http://www.ncbi.nlm.nih.gov/pubmed/21993451 JevitaPotheegadoo ChristineCuervo-Lombard FabriceBerna Jean-MarieDanion article 1002 Conscious Cogn 2012 21 247-257 Schizophrenia is a severe mental illness, which affects sense of identity. While the ability to have a coherent vision of the self (i.e., self-images) relies partly on its reciprocal relationships with autobiographical memories, little is known about how memories ground "self-images" in schizophrenia. Twenty-five patients with schizophrenia and 25 controls were asked to give six autobiographical memories related to four self-statements they considered essential for defining their identity. Results showed that patients' self-images were more passive than those of controls. Autobiographical memories underlying self-images were less thematically linked to these self-images in patients. We also found evidence of a weakened sense of self and a deficient organization of autobiographical memories grounding the self in schizophrenia. These abnormalities may account for the poor cohesiveness of the self in schizophrenia. http://www.ncbi.nlm.nih.gov/pubmed/22040535 MehdiBennouna-Greene FabriceBerna Martin AConway CJRathbone PierreVidailhet Jean-MarieDanion article 1001 Psychiatry Res 2012 While episodic memory impairment has been extensively studied in normal and pathological aging, studies investigating age-related episodic autobiographical memory among representative samples are scarce. We therefore investigated episodic autobiographical memory in a sample of 395 participants of a population-based prospective study of aging. Three groups were compared, consisting of 194 middle-aged participants, 138 healthy old-aged participants and 63 patients with mild cognitive impairment (MCI). Results showed a significant impairment of episodic autobiographical memory performance associated with MCI, but not with normal aging. These deficits were significantly correlated with verbal memory performances, but not with measures of executive functions. http://www.ncbi.nlm.nih.gov/pubmed/22520853 FabriceBerna PSchönknecht USeidl PToro JohanesSchröder article 1012 La Revue du Psychiatre 2011 7 44-47 French FabriceBerna MehdiBennouna-Greene Jean-MarieDanion article 1007 Schizophr Res 2011 128 156-160 BACKGROUND: Patients with schizophrenia exhibit a wide range of cognitive deficits, including autobiographical memory impairment. It has been suggested that there is a link between this impairment and a disorganization of autobiographical knowledge. This study aimed to explore both the elementary and conceptual organization of autobiographical memory in schizophrenia. METHODS: We used an event-cueing procedure to obtain and compare ten chains of six inter-related autobiographical memories of eighteen patients with schizophrenia and seventeen control participants. Elementary organization, which relies on memories' basic characteristics, including sensory-perceptive, cognitive, affective and temporal ones, was assessed by calculating the degree of similarity of the memories' characteristics within chains. Cluster-type connectivity, a form of conceptual organization reflecting the ability to organize autobiographical information about sets of causally and thematically related events, was assessed by asking the participants to describe the type of relationship between cued and cueing autobiographical memories. RESULTS: Whereas in controls elementary organization of memories relied on sensory-perceptive and cognitive characteristics of the memories, in patients it was mostly based on the memories' emotional content. Temporal organization and conceptual organization appeared to be preserved in patients. CONCLUSIONS: Patients fail to use sensory-perceptive and cognitive characteristics of memories to organize autobiographical knowledge. Possibly to compensate for this, they rely more on the memories' emotional characteristics. Our results point towards an imbalance between emotional and non-emotional factors underlying the organization of autobiographical memory in schizophrenia. http://www.ncbi.nlm.nih.gov/pubmed/21382696 ChristineMorise FabriceBerna Jean-MarieDanion article 1006 Psychiatry Res 2011 30 49-54 Although schizophrenia alters the sense of personal identity, little is known about the impact of illness-related autobiographical events on patients' self-representation. We investigated self-defining memories (SDM) in 24 patients with schizophrenia and 24 controls to explore how illness-related SDM were integrated into the self at both the cognitive (how participants are able to give a meaning to past events: meaning making) and affective levels (how participants can re-experience past negative events as less negative: redemption and benefaction effects). We found that 26% of freely recalled SDM referred to their illness in patients. Further, while meaning making was impaired in patients for both illness-related and other SDM, illness-related SDM were characterized by a higher redemption and benefaction effects than other SDM. Our results highlight that despite a reduced ability to give a meaning to illness-related episodes, emotional processing seems to allow these events to become positively integrated into patients' life stories. This study provides new findings about the construction of the self in relation to psychotic episodes in patients with schizophrenia. We discuss clinical implications of our results that are helpful to guide cognitive interventions. http://www.ncbi.nlm.nih.gov/pubmed/21459459 FabriceBerna MehdiBennouna-Greene JevitaPotheegadoo PVerry Martin AConway Jean-MarieDanion article 1005 Conscious Cogn 2011 20 703-711 Schizophrenia is a severe mental illness affecting sense of identity. Autobiographical memory deficits observed in schizophrenia could contribute to this altered sense of identity. The ability to give a meaning to personally significant events (meaning making) is also critical for identity construction and self-coherence. Twenty-four patients with schizophrenia and 24 control participants were asked to recall five self-defining memories. We assessed meaning making in participants' narratives (spontaneous meaning making) and afterwards asked them explicitly to give a meaning to their memories (cued meaning making). We found that both spontaneous and cued meaning making were impaired in patients with schizophrenia. This impairment was correlated with executive dysfunctions and level of negative symptoms. Our results suggest that patients' difficulties in drawing lessons about past experiences could contribute to explain the lack of coherence observed in their life trajectories and their impaired social adjustment abilities. Implications for psychotherapy are also discussed. http://www.ncbi.nlm.nih.gov/pubmed/21459619 FabriceBerna MehdiBennouna-Greene JevitaPotheegadoo PVerry Martin AConway Jean-MarieDanion article 1004 Child Abuse Negl 2011 35 329-332 OBJECTIVE: To determine the prevalence of five forms of abuse/neglect during childhood and adolescence in a group of schizophrenic patients with a history of violence. METHODS: Twenty-eight patients hospitalized in a highly secured psychiatric unit were included. Abuse and neglect during patients' growth were evaluated with the childhood trauma questionnaire (CTQ). History of substance abuse (consumption of cannabis, and/or alcohol, and/or heroin, and/or cocaine during the year that preceded the hospitalization), incarceration, and death of a close parent were also collected. RESULTS: We found that 46.4% of patients experienced at least 1 form of abuse and/or neglect during childhood and 21.4% of them had experienced more than 2 forms of abuse and/or neglect. The 2 most frequent forms of neglect and abuse were physical abuse (39.3%) and emotional neglect (17.9%). History of substance abuse was found for cannabis (57.1%), alcohol (57.1%), and cocaine and/or heroin (35.7%). We found that 42.8% of patients had 1 close relative who had died during their growth and that 41.6% of these deaths were violent. CONCLUSION: It appears important to systematically search for and assess a history of abuse and neglect during growth in schizophrenic patients with a history of violence, in order to offer specific treatments for this group of patients. http://www.ncbi.nlm.nih.gov/pubmed/21620159 MehdiBennouna-Greene ValérieBennouna-Greene FabriceBerna LucDefranoux inbook 402 2011 64-74 “Angst-Glücks-Psychose” has several translations in the literature: anxiety-happiness psychosis (AHP), anxiety-elation or anxiety-bliss psychosis. AHP is one of the 3 phenotypes of the cycloid psychosis (CP) as defined by the Wernicke-Kleist-Leonhard (WKL) school [26]. CP are bipolar psychoses in that they manifest in two opposite clinical pictures that may alternate from one episode to the next or during the same episode (mixed state). AHP as all CP has a purely relapsing-remitting course without accumulation of other symptoms between episodes; this can be opposed to nonsystematic schizophrenias that come with an initial episodic course as well, but where residual symptoms, e.g. lameness, indifference of affect up to flatness or blunting, loss of drive, but also other symptoms such as paranoia, hallucination, language disorders, increase at each remission. Psychosis or emotional disturbance could either appear as prevalent to a ICD/DSM formatted mind, but this symptomatology is too rough to distinguish them from non-systematic schizophrenias. WKL http://paperc.de/16055-das-glueck-9783898386470#!/pages/I fileadmin/Restreint/Anxiety-happiness_psychosis.pdf Johannes Schröder und Frank G. Brecht Akademische Verlagsgesellschaft GmbH

Heidelberg

IX. Symposium zur interdisziplinären Arbeit in der Sozialpsychiatrie Das Glück: Eine interdisziplinäre und klinische Betrachtung Jack RFoucher ValérieBennouna-Greene FabriceBerna BrunoPfuhlman GeraldStöber article 1010 Neurologies 2010 13 29-30 French FrédéricBlanc FabriceBerna article 1011 Revue Neurologique 2010 166 39-48 French FrédéricBlanc FabriceBerna MarieFleury LLita ElisabethRuppert DFerriby PatrickVermesch PierreVidailhet Jerômede Seze article 1008 Psychiatry Res 2010 179 1-5 The frequency of true and false autobiographical memories and associated states of conscious awareness, i.e., conscious recollection and simply knowing, as well as the respective roles of affective and cognitive processes in autobiographical memory construction, were assessed in eight patients with schizophrenia and eight control participants. A diary study methodology was used in combination with the Remember/Know procedure. The results showed a higher frequency of Know responses associated with the retrieval of both true and false memories in patients than in control participants. Whereas control participants rated higher at retrieval than at encoding the distinctiveness and personal importance of events, as well as the extent to which events furthered current personal plans, patients exhibited an opposite pattern of ratings, with ratings being lower at retrieval than at encoding. These preliminary results show a high frequency of simply knowing associated with the retrieval of true and false autobiographical memories in patients with schizophrenia and provide evidence for the interest of the diary study methodology for studying autobiographical memory in schizophrenia. http://www.ncbi.nlm.nih.gov/pubmed/20478623 ElodiePernot-Marino CarolineSchuster GHédelin FabriceBerna Marie-AgatheZimmermann Jean-MarieDanion book 1013 2009 65-75 Masson

Paris

Journées Pierre Denicker 8ème journée Pierre Denicker FabriceBerna MehdiBennouna-Greene Jean-MarieDanion article 1009 Can J Psychiatry 2007 52 693-701 OBJECTIVE: To achieve a better understanding of the functional mechanisms underlying episodic memory dysfunction in schizophrenia, which is a prerequisite for unravelling schizophrenia's neural correlates in neuroimaging studies and, more generally, for developing an integrated approach to the pathophysiology of schizophrenia. It is also crucial for developing cognitive remediation. METHOD: This paper reviews empirical evidence of episodic memory dysfunction in schizophrenia obtained with reference to various theoretical models of episodic memory. RESULTS: All the studies converge to show a significant impairment of the critical feature of episodic memory: conscious recollection. Schizophrenia is also associated with a defect of autobiographical memory. The episodic memory dysfunction results from a predominant failure of strategic processing at encoding, although an impairment of strategic processing at retrieval cannot be ruled out. The possibility that it is not the execution of the encoding strategies that is defective but, rather, their self-initiation by the patients is plausible. CONCLUSIONS: These findings may explain some behavioural abnormalities associated with schizophrenia, notably, inadequate functional outcomes in everyday life. They may also have implications for cognitive remediation and better social and work functioning of patients with schizophrenia. http://www.ncbi.nlm.nih.gov/pubmed/18399036 Jean-MarieDanion CarolineHuron PierreVidailhet FabriceBerna